Title

Patterns of psychiatric adverse drug reactions at an Eastern Indian tertiary care hospital

Authors

Krishnasish Das¹+, Prasanjit Das²+, Bisweswar Ojha³, Alapan Das², Tirthankar Deb*, ¹, Soumitra Mandal¹ & Sukriti Mukherjee⁴

Affiliation

¹Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Kalyani, West Bengal, India; ²Department of Pharmacology, Krishnanagar Institute of Medical Sciences, Krishnanagar, West Bengal, India; ³Department of Pharmacology, Manipal Tata Medical College, Jamshedpur, Jharkhand, India; ⁴Department of Psychiatry, Mandakini Institute of Medical Sciences and Hospital, Aistala, Ranaghat, West Bengal, India; *Corresponding author +Equally Contributed

Email

Krishnasish Das - E-mail: kdasexams@gmail.com; Phone: +91 7980781112
Prasanjit Das - E-mail: docprasanjitdas@gmail.com; Phone: +91 9074384749
Bisweswar Ojha - E-mail: bisweswar.ojha@manipal.edu; Phone: +91 8584065855
Alapan Das - E-mail: newborn91@gmail.com; Phone: +91 7001737617
Tirthankar Deb - E-mail: tirthankar.pharma@aiimskalyani.edu.in; Phone: +91 9088859953
Soumitra Mandal - E-mail: soumitra.pharma@aiimskalyani.edu.in; Phone: +91 7055241906
Sukriti Mukherjee - E-mail: mukherjeesukriti@gmail.com; Phone: +91 8240249265

Article Type

Research Article

Date

Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026

Abstract

Adverse drug reactions (ADRs) are an important cause of treatment-related morbidity in psychiatric practice, yet data describing their clinical profile from Eastern India remain limited. Among 150 reported ADRs, females accounted for 69.3% of cases, central nervous system reactions were the most frequent (52%), followed by metabolic/endocrine (16.7%) and gastrointestinal (13.3%) reactions, while sedation (18%), weight gain (13.3%) and drowsiness (12%) were the commonest adverse events, with escitalopram, lithium and olanzapine being the most frequently implicated drugs. Most ADRs were classified as probable (63.3%), mild (96.7%) and probably preventable (60%), whereas serious ADRs were uncommon (2%). Thus, data shows that psychiatric ADRs in routine clinical practice are largely mild and preventable, supporting the need for strengthened pharmacovigilance, early detection and systematic monitoring to improve the safety of psychopharmacotherapy. v

Keywords

Adverse drug reactions (ADRs), pharmacovigilance, psychiatry, psychotropic drugs and spontaneous reporting

Citation

Das et al. Bioinformation 22(9): 5985-5990 (2026)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.