Title

Potential role of ferroptosis in diabetic periodontitis: current evidences and clinical implications - A review

Authors

P. Arundhathi*, Sarja Ishwarya, Mundoor Manjunath Dayakar, Prakash Pai Gurupur & K. Sampath kumar Rao

Affiliation

Department of Periodontology & Oral Implantology, K. V. G Dental College and Hospital, Sullia, Dakshina Kannada, Rajiv Gandhi University of Health Sciences, Karnataka, India; *Corresponding author

Email

P. Arundhathi - E-mail: drarundhathiprabhakar@gmail.com
Sarja Ishwarya - E-mail: ishwaryasarja324@gmail.com
Mundoor Manjunath Dayakar - E-mail: mmdayakar@yahoo.com
Prakash Pai Gurupur - E-mail: prakashpaipai2014@gmail.com
K. Sampath Kumar Rao - E-mail: samrao99@gmail.com

Article Type

Review

Date

Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026
 

Abstract

Diabetic periodontitis is driven by hyperglycaemia and periodontal inflammation through a bidirectional relationship. Ferroptosis, an iron-dependent form of regulated cell death, has emerged as a key mechanism in both diseases. It promotes oxidative stress, inflammation and alveolar bone loss under hyperglycaemic conditions. Dysregulation of GPX4, SLC7A11 and transferrin receptor supports ferroptosis as a mechanistic link. Thus, ferroptosis is a promising mechanistic and therapeutic target for diabetic periodontitis.

Keywords

Ferroptosis, diabetic periodontitis, lipid peroxidation, glutathione peroxidase 4 (GPX4), oxidative stress, iron metabolism, alveolar bone resorption, periodontal disease

Citation

Arundhathi et al. Bioinformation 22(9): 6063-6066 (2026)

Edited by

Ruby Singh

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.