Title

Comparative efficacy of platelet-rich fibrin matrix versus guided tissue regeneration membrane with DFDBA in immediate implant placement: A randomized controlled clinical trial

Authors

Amit Mihani¹,*, Sachin Malagi¹, Priyamvada Bhatia², Rangoli Bhirad¹, Aditi R. Gupta³ & Roma Mihani⁴

Affiliation

¹Department of Periodontology, Maitri College of Dentistry and Research Centre, Anjora, Durg, Chhattisgarh, India; ²Department of Oral and Maxillofacial Surgery, Maitri College of Dentistry and Research Centre, Anjora, Durg, Chhattisgarh, India; ³Department of Periodontology, Pacific Dental College and Hospital, Debari, Udaipur, Rajasthan, India; ⁴Department of Pedodontics, Maitri College of Dentistry and Research Centre, Anjora, Durg, Chhattisgarh, India; *Corresponding author

Email

Sachin Malagi - E-mail: drmalagisachin@gmail.com
Priyamvada Bhatia - E-mail: drpriyamvada.bhatia@gmail.com
Rangoli Bhirad - E-mail: rangolibhirad1996@gmail.com
Aditi R. Gupta - E-mail: dr.aditig.30498@gmail.com
Roma Mihani - E-mail: mihaniroma@gmail.com

Article Type

Research Article

Date

Received September 1, 2026; Revised September 30, 2026; Accepted September 30, 2026, Published September 30, 2026
 

Abstract

Management of the peri-implant jumping distance remains challenging during immediate implant placement because inadequate bone fill may compromise osseointegration. This randomized trial included 30 systemically healthy patients receiving DFDBA with GTR membrane (n=15) or autologous PRFM (n=15) using a two-stage protocol. Plaque, gingival, bleeding, probing depth, attachment loss and crestal bone levels were assessed at baseline, 3 and 6 months and post-restoration. Both groups achieved 100% implant survival and success, with healthy probing depths and progressive reductions in plaque and gingival inflammation. No significant intergroup differences were observed, indicating comparable clinical outcomes with DFDBA combined with GTR membrane or PRFM.

Keywords

Platelet-rich fibrin matrix (PRFM), guided tissue regeneration (GTR) membrane, DFDBA, immediate implant placement, randomized controlled trial, bone regeneration

Citation

Mihani et al. Bioinformation 22(9): 6125-6129 (2026)

Edited by

Ruby Singh

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.