Title

Comparing intracanal medicaments and their action against Enterococcus faecalis

Authors

Meenal Doshi, Nitin Kararia*, Shyam Agrawal, Naveen Chaudhary, Sameeha Khajuria & Wairokpam Devi Digantic

Affiliation

Department of Conservative Dentistry & Endodontics, Nims Dental College & Hospital, Nims University Rajasthan, NH-11C, Jaipur-Delhi Highway, Jaipur, Rajasthan, India; *Corresponding author

Email

Meenal Doshi - E-mail: doshimeenal6@gmail.com
Nitin Kararia - E-mail: amazingsaggian@gmail.com
Shyam Agrawal - E-mail: agrawal.drshyam@gmail.com
Naveen Chaudhary - E-mail: nvnchaudhary@gmail.com
Sameeha Khajuria - E-mail: sameehakhajuria13@gmail.com
Wairokpam Devi Digantic - E-mail: dr.digantic@gmail.com
 

Article Type

Research Article

Date

Received October 1, 2026; Revised October 31, 2026; Accepted October 31, 2026, Published October 31, 2026

Abstract

Complete elimination of microorganisms is essential for endodontic success, but Enterococcus faecalis frequently persists in treated canals. Therefore, it is of interest to compare the triple antibiotic paste (TAP), 0.05% octenidine dihydrochloride (OD) and Ca(OH)2 + 2% chlorhexidine against E. faecalis. Eighty extracted single-rooted teeth were inoculated for 14 days and randomly assigned to four groups (n=20), with bacterial counts assessed before and after treatment. All experimental groups significantly reduced bacterial counts (P<0.05), with TAP showing the greatest reduction (95.74%), followed by Ca(OH)2 + CHX (93.86%) and OD (92.84%). Thus, TAP showed the highest antibacterial efficacy, while Ca(OH)2 + CHX and OD showed substantial activity against E. faecalis.

Keywords

Intracanal medicament, triple antibiotic paste (TAP), octenidine dihydrochloride (OD), calcium hydroxide, chlorhexidine, Enterococcus faecalis, colony-forming units

Citation

Doshi et al. Bioinformation 22(10): 6830-6834 (2026)

Edited by

Ruby Singh

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.