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Title |
Evaluation of L-arginine and copper oxide nanoparticle-based ointment for in vitro angiogenic enhancement in diabetic wound healing
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Author names |
R. Geetha* & R. Dhineka Department of Biotechnology, Periyar Maniammai Institute of Science and Technology, Vallam, Thanjavur
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R. Geetha - E-mail: headbio@pmu.edu R. Dhineka - E-mail: dhinekaswedhika@gmail.com
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Abstract |
Impaired wound healing remains major clinical concern due to infection, persistent inflammation, and inadequate tissue regeneration. Nano-enabled biomaterials offer promising solutions by integrating antimicrobial and bioactive functions. In this study, copper oxide nanoparticles (CuO NPs) were synthesized via controlled chemical precipitation and characterized using UV Visible spectroscopy, scanning electron microscope and Fourier Transform Infrared (FTIR) analysis, confirming nanoscale formation and CuO bond signatures. The nanoparticles were incorporated into an arginine-based hydrophilic ointment to develop a multifunctional topical formulation. Arginine was selected for its role in nitric oxide mediated immune modulation, fibroblast proliferation, and angiogenic signalling. The formulated CuO arginine ointment exhibited skin-compatible pH, uniform nanoparticle dispersion, desirable semisolid consistency. Antimicrobial evaluation demonstrated significant inhibitory activity against tested bacterial strains, indicating synergistic antibacterial potential. These findings establish a proof of concept for a stable nano-bioactive wound healing system, warranting further investigation through cytocompatibility assays, nitric oxide profiling, and in vivo wound-closure studies to confirm therapeutic efficacy and translational potential. |
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Keywords
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Copper oxide Nanoparticles; arginine-based ointment; wound healing; nitric oxide modulation; angiogenesis; topical therapy
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Date: April 16, 2026 |
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