Disease associated cellular machinery in anaphylaxis

BACK TO CONTENTS | PDF | PREVIOUS | NEXT

Title	Disease associated cellular machinery in anaphylaxis – And the de novo paradigm shift
Authors	Peter Natesan Pushparaj¹*, Mahmood Rasool¹, Muhammad Imran Naseer¹, Laila Abdullah Damiati², Narasimhan Kothandaraman¹, Kalamegam Gauthaman¹, Sami Bhalas³ & Jayapal Manikandan⁴
Affiliation	¹Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; ²King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; ³Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia; ⁴Faculty of Life and Physical Sciences, The University of Western Australia (M011), 35 Stirling Highway, Crawley, WA 6009, Australia
Email	peter.n.pushparaj@gmail.com; *Corresponding author
Article Type	Review
Date	Received December 25, 2014; Accepted January 13, 2015; Published January 30, 2015
Abstract	Anaphylaxis is a sudden immune reaction against an allergen that can potentially lead to Anaphylactic Shock (AS). This immune reaction is characterized by an increase in Immunoglobulin-E (IgE) type of antibodies that bind with FcεRI receptors on mast cells to release inflammatory mediators. Various intracellular signaling molecules downstream of IgE/ FcεRI axis play a potential role in cytokine, chemokine and eicosanoid secretion as well as degranulation of immune cells causing vasodilation, vascular permeability, and reduction of intravascular volume leading to cardiovascular collapse. Here, we discuss the cellular machinery of anaphylaxis and the de novo paradigm shift in the cellular aspects of AS.
Keywords	Anaphylaxis, Anaphylactic shock, Immunoglobulin E, Mast cells, Cytokines, Chemokines, Paradigm shift
Citation	Pushparaj et al. Bioinformation 11(1): 043-046 (2015)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.