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Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant



Jayaraman Selvaraj1, Rajamanickam Pon Nivedha2, Periyasamy Vijayalakshmi3, Rajagopal Ponnulakshmi4*



1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Exonn Biosciences, Ticel Bio Park, Chennai 600 0113; 3PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy- 620002, Tamil Nadu, India; 4Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India



Dr. Rajagopal Ponnulakshmi E-mail: ramgslaks@gmail.com; *Corresponding author:


Article Type

Research Article



Submitted on March 30, 2020; Revision June 9, 2020; Accepted June 11, 2020; Published July 31, 2020



Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.



Alzheimer's disease, Protein Network analysis, Gymnema sylvestre, Molecular docking



Selvaraj et al. Bioinformation 16(7): 561-566 (2020)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.