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Title

Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant

 

Authors

Jayaraman Selvaraj1, Hussain Sardar2, Veeraraghavan Vishnupriya3, Janardhana Papayya Balakrishna4, Surapaneni Krishna Mohan5, Rajamanickam Pon Nivedha6, Periyasamy Vijayalakshmi7, Rajagopal Ponnulakshmi8*

 

Affiliation

1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 2Department of Biotechnology, Government Science College, Chitradurga-577501, Karnataka, India; 3Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 4Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, India; 5Department of Biochemistry and Department of Clinical Skills & Simulation, Panimalar Medical College Hospital & Research Institute, Varadharajapuram, Poonamallee, Chennai - 600 123, India; 6Exonn Biosciences, Ticel Bio Park, Chennai-600 0113, India; 7PG & Research Department of Biotechnology & Bioinformatics, Holy Cross College (Autonomous), Trichy- 620002, Tamil Nadu, India; 8Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; Dr. Rajagopal Ponnulakshmi E-mail: ramgslaks@gmail.com; *Corresponding author:

 

Email

Dr. Rajagopal Ponnulakshmi E-mail: ramgslaks@gmail.com; *Corresponding author:

 

Article Type

Research Article

 

Date

Submitted on March 30, 2020; Revision June 9, 2020; Accepted June 11, 2020; Published July 31, 2020

 

Abstract

Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.

 

Keywords

Alzheimer's disease, Protein Network analysis, Gymnema sylvestre, Molecular docking

 

Citation

Selvaraj et al. Bioinformation 16(7): 561-566 (2020)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.