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From network pharmacology to molecular docking analysis of sterubin targets for Alzheimer



Sittarthan Viswanathan 1,* Thennavan Arumugam2, Rengaraj Sivaraj3, Srihari Subhashri Rajendran1, Vimalavathini Ramesh1, Kavimani Subramanian1 & A. Hannah Rachel Vasanthi 4



1Department of Pharmacology, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Puducherry - 605006, India; 2Department of Pharmacology, Central Animal House, JIPMER, Puducherry - 605006; 3Department of Pharmacology, Aarupadai Veedu Medical College & Hospital, Puducherry 607402; 4Department of Biotechnology, Pondicherry University - 605014; *Corresponding author



Sittarthan Viswanathan - E-mail: insiddhu@gmail.com

Thennavan Arumugam - E-mail: Thennavan.a.u@gmail.com

Rengaraj Sivaraj - E-mail: sivaraj.rengaraj@avmc.edu.in

Shrihari Subhashri Ranjendran - E-mail: subhasnow23@gmail.com

Ramesh Vimalavahani - E-mail: vimalavathini@gmail.com

Hannah Rachel Vasanthi - E-mail: hrvasanthi@gmail.com

Kavimani Subramanian - E-mail: drskavimani@yahoo.co.in


Article Type

Research Article



Received April 1, 2024; Revised April 30, 2024; Accepted April 30, 2024, Published April 30, 2024



Sterubin (7-O-Methyleriodicytol), a flavanone compound isolated from the leaves of Eriodicyton californicum and Eriodicyton angustifolium, has neuroprotective, anti-inflammatory, and antioxidant properties. Therefore, it is of interest to identify the potential targets for Alzheimer disease using network pharmacology. We report 25 overlapping targets among 100 potential targets of sterubin and 673 known targets of Alzheimer. APP, BACE-1, and AChE were among the ten hub targets enriched in biological processes and pathways relevant to Alzheimer's disease. Subsequent, molecular docking analysis shows that sterubin have optimal binding features with these hub gene targets for further consideration.



Network, pharmacology, molecular docking, sterubin, Alzheimer.



Vishwanathan et al. Bioinformation 20(4): 327-336 (2024)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.