Title

Injectable platelet rich fibrin versus low-level laser therapy for orthodontic tooth movement: A clinical split-mouth study

Authors

Sunilkumar Nagmode¹, Pranoti Gade^1,*, Kunal Patil¹, Hrushikesh Aphale1, Payal Barse¹ & Ekata Jaindesarda²

Affiliation

¹Department of Orthodontics and Dentofacial Orthopaedics, SMBT Dental College and Hospital Ghulewadi, Sangamner, Maharashtra, India; ²Department of Periodontology, SMBT Dental College and Hospital Ghulewadi, Sangamner, Maharashtra, India; *Corresponding author

Email

Sunilkumar Nagmode - E-mail: drnagmode77@gmail.com
Pranoti Gade - E-mail: pranotigade403@gmail.com
Kunal Patil - E-mail: kunalpatilortho@gmail.com
Hrushikesh Aphale - E-mail: Hrushikeshaphale@gmail.com
Payal Barse - E-mail: payalbarse1310@gmail.com
Ekata Jaindesarda - E-mail: ekatajain75@gmail.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

Accelerating tooth movement during orthodontic treatment is a growing focus in clinical orthodontics. Techniques like injectable platelet rich fibrin (i-PRF) and Low-Level Laser Therapy (LLLT) have demonstrated encouraging results. Hence, 20 patients aged 18-25 years were enrolled and one side of their maxillary arch was injected with intraligamental and submucosal i-PRF and the opposite side with LLLT (980nm, 100mW). Measurements were taken using digital vernier calliper on distal surface of canine to mesial surface of second premolar monthly for four months. The mean rate of space closure on i-PRF side (right) was significantly higher (2.85 ± 0.47 mm) than LLLT side (2.05 ± 0.28 mm; p<0.001). The left side (control group) showed no significant difference (p=0.833). Thus, i-PRF is more effective than LLLT in accelerating orthodontic tooth movement. Further multicentre trials are recommended.

Keywords

Platelet rich fibrin, low-level laser therapy, orthodontic tooth movement, split mouth study

Citation

Nagmode et al. Bioinformation 21(9): 3345-3349 (2025)

Edited by

Neelam Goyal & Shruti Dabi

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.