Title
Retrospective cohort study on long-term anticoagulation therapy for bleeding complications among atrial fibrillation patients
Authors
Megha Joy1, Bethamcherla Bala Chandrudu2, Mohamed Thoufeek Hussain Amjat Ibrahim3,*, Richard Fleming4 & Harish Sidharth Veerachamy5
Affiliation
1Department of Internal Medicine, Queen Elizabeth Queen Mother Hospital, Margate, United Kingdom; 2Department of Medical Physiology, Visvabharathi Medical College and General Hospital, Penchikalapadu, Andhra Pradesh, India; 3Department of Vascular Surgery, Apollo main hospital, Karpaga Vinayaga Institute of medical science and research center, Tamil Nadu, India; 4Department of General Medicine, Snehadaan Hospital, Bengaluru, Karnataka; 5Department of General Medicine, Tirunelveli Medical College, Tamil Nadu, India; *Corresponding author
Megha Joy - E-mail: megha.joy@nhs.net; Phone: +447585664581
Bethamcherla Bala Chandrudu - E-mail: balachandrudu.b@gmail.com;
Phone: +91 9440511846/ 9493751346
Mohamed Thoufeek Hussain Amjat Ibrahim - E-mail: thoufeek.hussain@gmail.com;
Phone: +91 89705 59967
Richard Fleming - E-mail: richardfleming97@gmail.com; +91 8075030527
Harish Sidharth Veerachamy - E-mail: harishsidharth0504@gmail.com;
Phone: +91 9443418800
Article Type
Research Article
Date
Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract
The frequencies and contributing factors to bleeding complications among atrial fibrillation patients on a regimen of long-term oral anticoagulants is of interest. The medical records for 142 patients treated with either warfarin or direct oral anticoagulants (DOACs) were assessed over a period of three years. Major and minor bleeding episodes were associated with instability of the international normalized ratio (INR), the type of anticoagulant medication, and individual patient characteristics. The bleeding complications were observed to occur more frequently with patients presenting with unstable INR values and those treated with warfarin in contrast to DOACs patients. Thus, the importance of a tailored anticoagulation regimen to address bleeding complications in atrial fibrillation is shown.
Keywords
Warfarin, DOACs, anticoagulation, bleeding risk, atrial fibrillation, INR fluctuation, and long-term treatment
Citation
Joy et al. Bioinformation 21(9): 3417-3419 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
