Title

Gender differences in outcomes among patients with heart failure and preserved ejection fraction: a retrospective cohort study

Authors

Vidhi Jagdishkumar Sonara¹, Rekha Joe², Glenn Jo³, Tania George⁴, Vinupriya Talari^5,* & Anand Anilkumar⁶

Affiliation

¹Department of Respiratory Medicine, Medical Officer, Government Medical College, Surat, Gujarat, India; ²Department of Interventional Radiology, GMC, Kalamassery, Kochi, Kerala, India; ³Department of General Medicine, RMO, Kerala State Medical Councils, Kunnukuzhy, Thiruvananthapuram, Kerala, India; ⁴Department of Cardiology, Baby Memorial Hospital, Kozhikode, Kerala, India; ⁵Department of Cardiology, Yashoda Hospitals, Hyderabad, Telangana, India; ⁶Department of General Medicine, Aster MIMS, Kannur, Kerala, India; *Corresponding author

Email

Vidhi Jagdishkumar Sonara - E-mail: sonara.vidhi15@gmail.com; Phone: +91 9537478999
Rekha Joe - E-mail: rekhajoe83@gmail.com; Phone: +91 9645916523
Glenn Jo - E-mail: Drglennjo@gmail.com; Phone: +91 9731182257
Tania George - E-mail: taniageop@gmail.com; Phone: +91 8301045675
Vinupriya Talari - E-mail: Vinu.priya232@gmail.com; Phone: +91 6302239202
Anand Anilkumar - E-mail: anandanilkumar07@gmail.com; Phone: +91 9447486808

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Gender differences in the clinical presentation and outcomes of heart failure with preserved ejection fraction (HFpEF) remain inadequately characterized. This retrospective cohort study evaluated 146 HFpEF patients to compare baseline features and one-year outcomes between males and females. Female patients were more frequently obese or hypertensive, whereas male patients more often had coronary artery disease. Despite these differing risk profiles, females exhibited lower mortality and all-cause hospitalization rates at one year. These findings underscore meaningful gender-based variations in HFpEF and support the need for gender-sensitive strategies in clinical management and prognostication.

Keywords

Heart failure, HFpEF outcomes, hospitalization, death, gender differences and preserved ejection fraction

Citation

Sonara et al. Bioinformation 21(12): 4355-4358 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.