Title
Hepatic and muscular glycogen storage diseases: A narrative review of therapeutic interventions and long-term outcomes
Authors
Husam Abdo Mohammed Mohammed Abdulrazzaq*, Mena Afghan Yar & Roya Barakzai
Affiliation
Department of Fundamental Medicine, Faculty of Medicine and Health care, Farabi University, Almaty, Kazakhstan; *Corresponding author
Husam Abdo Mohammed Mohammed Abdulrazzaq - E-mail: husamabdo100@gmail.com; Phone: +966 551015080
Mena Afghan Yar - E-mail: afgan_yar_mena@live.kaznu.kz; Phone: +7 7029842756
Roya Barakzai - E-mail: barakzai_roya@live.kaznu.kz; Phone: +7 7072822310
Article Type
Review
Date
Received July 1, 2026; Revised July 31, 2026; Accepted July 31, 2026, Published July 31, 2026
Abstract
Glycogen storage diseases (GSDs) are inherited metabolic disorders affecting hepatic or muscular glycogen metabolism. Hepatic and muscular GSDs diverge fundamentally in pathophysiology, driving distinct clinical priorities and outcome measures. Hepatic GSDs require sustained systemic metabolic control, primarily dietary management, to prevent hypoglycemia and long-term complications such as hepatic adenomas and nephropathy. Muscular GSDs are managed through functional adaptation, including structured exercise training and, in Pompe disease, enzyme replacement therapy, to improve exercise tolerance and motor function. Despite these tailored strategies, complications persist in both forms, underscoring the need for phenotype-driven management and standardized outcome measures across the GSD spectrum.
Keywords
Glycogen storage diseases (GSDs); hepatic glycogen storage disease; muscular glycogen storage disease; metabolic control; therapeutic outcomes
Citation
Abdulrazzaq et al. Bioinformation 22(7): 4472-4475 (2026)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
